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The University of Massachusetts is leading the New England node for that effort. The U. Before Harry Bermudez was even born, his parents decided to pack up and leave their home, family, and friends in Colombia to make a new life in New York City. But economic and political factors drove them to the U. The design for the Roll to Roll Fabrication and Processing Facility at the University of Massachusetts Amherst has been completed and tool acquisition is presently underway.

Traditional genomic, proteomic and other screening methods currently used to characterize drug mechanisms are time-consuming and require special equipment, but now researchers led by chemist Vincent Rotello at the University of Massachusetts Amherst offer a multi-channel sensor method using gold nanoparticles that can accurately profile various anti-cancer drugs and their mechanisms in minutes. Jim Watkins discusses how nanotechnology is being applied in developing cost-effective body sensor patches to measure stress in military personnel.

Fitness bands and other wearable health monitors are all the rage among runners and other athletes who want to keep track of their workouts and measure vital statistics such as heart rate and calories burned. Now military personnel may soon have access to the same technology, in a patch that would be about the size and shape of a Band-Aid, and as flexible.

Based on research from the University of Massachusetts Amherst, the sensor would gauge stress and fatigue among armed services personnel. Conte Distinguished Professor in the department of polymer science and engineering. Blood 81 : — Galy A. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset.

Immunity 3 : — Guenechea G. Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Hao Q. Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88 : — Harrison D. Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. Hirsch E. Hosen N. Bmigreen fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells.

Stem Cells 25 : — Huang S. Blood 83 : — Ikuta K. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Jaiswal S. Jamieson C. Chronic versus acute myelogenous leukemia: A question of self-renewal. Cancer Cell 6 : — Medline Web of Science Google Scholar. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. Karanu F. The Notch ligand Jagged-1 represents a novel growth factor of human hematopoietic stem cells.

Kiel M. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Kimura T. Simultaneous activation of signals through gp, c-kit, and interleukin-3 receptor promotes a tri-lineage blood cell production in the absence of terminally acting lineage-specific factors. Blood 90 : — Kogan S. Kondo M.

Scientific Establishments and Hierarchies

Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91 : — Konopleva M. Br J Haematol. Krause D.


  • Loose Threads.
  • Asynchronous System-on-Chip Interconnect;
  • Everest the West Ridge?

CD Structure, biology, and clinical utility. Blood 87 : 1 — Kroon E. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. Lagasse E. Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Lapidot T. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Larochelle A.

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Lavau C. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Lessard J. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Majeti R. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.

Manz M. Prospective isolation of human clonogenic common myeloid progenitors. Mazurier F. Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood : — McKenzie J. Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment.

Michallet M. Exp Hematol. Miller J. Blood 93 : 96 — Miyamoto T. Mohle R.

Dominance Hierarchy

Morrison S. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1 : — Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5 : — Identification of a lineage of multipotent hematopoietic progenitors.

Scientific Establishments and Hierarchies - Google книги

Development : — Nagasawa T. Negrin R. Biol Blood Marrow Transplant. Notaro R.

In vivo telomere dynamics of human hematopoietic stem cells. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Osawa M. Science : — Papayannopoulou T. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Peled A. Blood 95 : — Petzer A. Self-renewal of primitive human hematopoietic cells long-term-culture-initiating cells in vitro and their expansion in defined medium.

Potocnik A. Immunity 12 : — Raaphorst F. Self-renewal of hematopoietic and leukemic stem cells: A central role for the Polycomb-group gene Bmi-1 Trends Immunol. Reya T. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Robertson M. Lymphoma 17 : 51 — Sauvageau G. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Siminovitch L. The distribution of colony-forming cells among spleen colonies. J Cell Physiol. Smith L. Clonal analysis of hematopoietic stem-cell differentiation in vivo.

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 3 : — Spangrude G. Purification and characterization of mouse hematopoietic stem cells. Science : 58 — Thorsteinsdottir U. Enhanced in vivo regenerative potential of HOXB4 -transduced hematopoietic stem cells with regulation of their pool size. Blood 94 : — Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion.